Ending Aging

Buchzusammenfassung

Aubrey de Grey, PhD, is chief science officer and chairman of the Methuselah Foundation. As a biomedical gerontologist, he is one of the most active scientists in the fight to stop aging. He developed the SENS program to stop aging. Currently, he organizes conferences and workshops to promote further research.

The author explores the inevitability of aging and its root causes, such as the accumulation of advanced glycation endproducts (AGEs), toxic "zombie cells," mitochondrial mutations, and cellular waste like lipofuscin and amyloids. While prevention and cures for aging remain elusive, the focus shifts to repair strategies, including gene therapy, stem cell research, and innovative approaches like allotopic expression to protect mitochondrial DNA. Ethical and practical challenges, such as the use of embryonic stem cells and the risks of cancer, are acknowledged, alongside the potential of groundbreaking solutions like vaccinations and microbial interventions to combat cellular damage. Through the SENS program and initiatives like robust mouse rejuvenation (RMR), the author envisions a future where aging could be mitigated or even reversed, despite current funding and societal hurdles. The next section will further examine how cellular and extracellular waste contributes to aging and the strategies proposed to address it.

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